Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
نویسندگان
چکیده
منابع مشابه
Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats.
Antipsychotics are an important class of drugs for the management of schizophrenia and other psychotic disorders. They act by blocking dopamine receptors; however, because these receptors are present throughout the brain, prolonged antipsychotic use also leads to serious side effects. These include tardive dyskinesia, repetitive abnormal involuntary movements of the face and limbs for which the...
متن کاملCrocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism
Objective(s):Long-term treatment with antipsychotics causes serious side effects such as tardive dyskinesia that characterized by abnormal movements in the orofacial region. Oxidative stress in the brain specific area is implicated in the pathophysiology of tardive dyskinesia. In this study the protective effect of crocin on haloperidol-induced orofacial dyskinesia was evaluated. Materials and ...
متن کاملReserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats.
The nigrostriatal dopaminergic system seems to be involved in both reserpine-induced orofacial dyskinesia in normal rats and in the pathogenesis of hypertension in spontaneously hypertensive rats. In the present study, repeated reserpine administration (1.0 mg/kg, s.c., every other day, for 3 days) increased tongue protrusion and vacuous chewing frequencies as well as the duration of facial twi...
متن کاملcrocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism
objective(s):long-term treatment with antipsychotics causes serious side effects such as tardive dyskinesia that characterized by abnormal movements in the orofacial region. oxidative stress in the brain specific area is implicated in the pathophysiology of tardive dyskinesia. in this study the protective effect of crocin on haloperidol-induced orofacial dyskinesia was evaluated. materials and ...
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The aim of the present study was to evaluate effect of ellagic acid, a polyphenol bioactive compound, on reserpine-induced orofacial dyskinesia in Wistar male albino rats and to explore the possible underlying mechanisms for this effect. Reserpine (1 mg kgG1, i.p.) was administered on every alternate day for a period of 5 days (day 1, 3 and 5) to induce orofacial dyskinesia in rats. Ellagic aci...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2011
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.111.189100